Section background
Glow beyond boundaries with CYNEFILL PICO PDRN

The best skin rejuvenating solution with pdrn, hyaluronic acid and glutathione

View our products
Want to buy mesotherapy products?
We appreciate you taking the time to reach out to our products list. If you couldn’t find the information you need don’t worry — just leave your contact details and one of our team members will be in touch shortly.

    ZK MediGroup | Biorevitalization
    Specifications
    The best skin rejuvenating solution with PDRN, Hyaluronic Acid and Glutathione.
    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    Glutathione
    Hyaluronic Acid
    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    DNА

    PolyDeoxyRiboNucleotide, in short, PDRN, is a substance extracted from the fragments of salmon DNA. Clinical studies have shown that salmon DNA has an excellent and significant effect on cell growth and tissue regeneration. It also improves skin elasticity,
    texture and hydration.

    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    Our cells naturally have DNA repair enzymes, however, they don’t work as well as we age. That is why wrinkles, spots, uneven skin tone and sagging skin start to appear after a certain age. Basically, ageing is a consequence of unrepaired accumulation of DNA damage. Therefore, salmon DNA is excellent to regenerate and repair damaged cells caused by aging and ultraviolet rays, which are the underlying factors for pigmentation skin, acne scars,dull and uneven skin tone, fine lines and wrinkles.
    Hyaluronic acid is naturally present in the human body as a component of the cell. With age,its content decreases and, as a result, the skin loses elasticity, the number of wrinkles increases. For dehydrated, losing skin elasticity delivery of hyaluronic acid directly to the subcutaneous layer is the most effective way to experience an immediate effect.
    effect.
    Read more

    Niacinamide is a typical whitening ingredient. Niacinamide, which is a B-group vitamin improves the skin’s moisture control function as a lipid activating material that plays the most important role in controlling moisture skin. It has excellent safety characteristics for skinstability, and is involved in the production of bioenergy, helping to whiten, moisturize and improve skin tone.

    ZK MediGroup | Biorevitalization ZK MediGroup | Biorevitalization ZK MediGroup | Biorevitalization ZK MediGroup | Biorevitalization ZK MediGroup | Biorevitalization ZK MediGroup | Biorevitalization ZK MediGroup | Biorevitalization
    How does it work

    The essence of the method is to inject an injection of absolutely identical natural hyaluronic acid into the papillary layer of the skin. Biorevitalization of the skin restores the lost hyaluronic acid in the dermis and thus suspends aging.

    Salmon
    dna
    ZK MediGroup | Biorevitalization ZK MediGroup | Biorevitalization
    After
    Before
    Application areas

    Absolutely new conception of prolonged biorevitalization presented as a CYNEFILL PICO PDRN, for restoration and enhancement of skin regeneration in delicate areas (orbital, perioral, neck, decollete)

    ZK MediGroup | Biorevitalization
    1
    Face
    ZK MediGroup | Biorevitalization
    2
    Оrbital
    ZK MediGroup | Biorevitalization
    3
    Perioral
    ZK MediGroup | Biorevitalization
    4
    Neck
    ZK MediGroup | Biorevitalization
    5
    Decollete
    Indications
    Stressed, tired skin
    Dry skin and loss of elasticity
    Atrophic scars, striae, flabbiness of the skin
    Increased pigmentation
    Restoration of the skin after winter
    "Smoker's skin”
    Shallow wrinkles (in particular, mimic) and signs of photo aging of the skin
    Cell regeneration
    Pore tightening
    Improves density of dermis
    ZK MediGroup | Biorevitalization
    Wound healing
    Improves skin tone
    Anti-implammatory
    Contraindications
    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    Absolute contraindications are:
    • Blood diseases;
    • Autoimmune disorders;
    • Oncologic diseases;
    • Allergy to the components of the drug;
    • Epilepsy and some other chronic diseases.
    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    Temporary contraindications are:
    • Аcute diseases;
    • Еxacerbation of chronic diseases;
    • Tendency to the formation of keloid scars;
    • Injuries, rashes on the skin in the area of injections;
    What to combine with
    Treatment combination illustration
    • Biorevitalization and Botox
    • Biorevitalization and contour plasty with fillers
    Duration of effect

    The effect of beauty injections lasts on average 4 – 6 months, after which the drug is slowly and without residue is excreted from the body naturally.

    ZK MediGroup | Biorevitalization
    PROTOCOL
    Introduction protocol:

    The product is administered intradermally or using the papul mesotherapy technique. A linear threading technique, serial puncture injections or a combination of the two have been used to achieve optimal results. The course of treatment is 3-4 times with an interval of 2-4 weeks. The procedure can be repeated every 6-9 months to maintain the effect. Recommended needle: 29-30G

    Treatment area:

    Face, wrinkles on the neck, stretch marks

    Ingredients:

    Polydeoxyribonucleotide, Hyaluronic Acid, Niacinamide, Gluthatione

    Packing:

    3 ml/5 vials

    Storage Precautions:

    Store between 15~25°C.
    Keep away from direct sunlight.

    ZK MediGroup | Biorevitalization
    Usage technique
    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    Picotage

    Picotage – microinjection technique. Injections are performed at a distance of 1 cm from each other with the introduction of the drug to a minimum depth.

    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    Linear

    Linear – a non-traumatic method that leaves virtually no traces on the skin. It is used to correct wrinkles and folds. This technique involves the introduction of biorevitalizant at a shallower depth

    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    "Point by point"

    “Point by point” – shallow introduction of injections along the lines of wrinkles. It is used to treat particularly sensitive areas of the face.

    ZK MediGroup | Biorevitalization
    ZK MediGroup | Biorevitalization
    Papular

    Papular is the most common method. After the injections, tiny bumps remain on the skin – locations of accumulation of the injected gel, which resorb after about 24 hours. The purpose of the papular technique is to ensure the long-term preservation of hyaluronic acid in the tissues.

    Effect after use
    CYNEFILL PICO PDRN's strengths:
    ZK MediGroup | Biorevitalization

    Reduction of undesirable pigmentation of the skin

    ZK MediGroup | Biorevitalization

    Activates skin microcirculation

    ZK MediGroup | Biorevitalization

    Treatment of early signs of aging (fine and superficial wrinkles)

    ZK MediGroup | Biorevitalization

    Repair of damaged skin (as a result of exposure to UV radiation and excessive cosmetic care)

    ZK MediGroup | Biorevitalization

    Improved elasticity, color and texture of the skin

    ZK MediGroup | Biorevitalization

    Stimulates the regeneration of all layers of the skin

    ZK MediGroup | Biorevitalization

    Prolonged skin moisturizing effec

    ZK MediGroup | Biorevitalization

    Restoration of the epidermal barrier

    ZK MediGroup | Biorevitalization

    Smoothing acne scars and other skin defects

    ZK MediGroup | Biorevitalization

    Improvement of the texture and color of the skin

    ZK MediGroup | Biorevitalization
    Benefits
    CYNEFILL PICO PDRN
    ZK MediGroup | Biorevitalization
    Fast results: The procedure allows you to get visible results almost immediately, without the need for months of skin regeneration.
    ZK MediGroup | Biorevitalization
    Guaranteed results: Unlike creams and masks, the results of which are difficult to predict, injections guarantee the desired effect. Of course, for optimal results, you should entrust your appearance to an experienced professional.
    ZK MediGroup | Biorevitalization
    Saving time: Regular biorevitalization procedures can significantly reduce the time spent on daily skin care, such as masks, massages and other manipulations. This frees up time for more interesting, enjoyable and productive activities.
    ZK MediGroup | Biorevitalization
    Safety and minimal risk of side effects: The procedure is considered safe because hyaluronic acid is a natural component of the skin.
    ZK MediGroup | Biorevitalization

    Frequently asked questions about biorevitalization

    • What is skin biorevitalization?

      Skin biorevitalization is a non-surgical cosmetic procedure that involves injecting hyaluronic acid and other active ingredients into the skin to restore hydration, elasticity, and overall skin health. A popular option is CYNEFILL PICO PDRN, a product from a Korean manufacturer known for its skin-rejuvenating properties.

    • Biorevitalization: how long does it last?

      The effects of biorevitalization typically last 3 to 6 months, depending on the individual’s skin condition and the products used. Treatments like CYNEFILL PICO PDRN may offer prolonged benefits due to its unique formula.

    • What is the biorevitalization treatment?

      Biorevitalization treatment involves a series of microinjections into the skin, targeting areas that need rejuvenation. CYNEFILL PICO PDRN is often used for its potent blend of PDRN (polydeoxyribonucleotide) and hyaluronic acid, which enhances skin regeneration and hydration.

    • How often should I do biorevitalization?

      It is generally recommended to undergo biorevitalization every 3 to 4 months to maintain results. However, the frequency may vary depending on skin type and the product used, such as CYNEFILL PICO PDRN.

    • Is biorevitalization good?

      Yes, biorevitalization is highly effective in improving skin texture, hydration, and elasticity. Products like CYNEFILL PICO PDRN are particularly praised for their ability to revitalize the skin, making it a popular choice for those seeking non-invasive rejuvenation.

    • What is the difference between biorevitalization and fillers?

      Biorevitalization primarily focuses on skin hydration and rejuvenation through microinjections of hyaluronic acid and other nutrients, while fillers are used to add volume to specific areas of the face. CYNEFILL PICO PDRN, used in biorevitalization, enhances skin quality, whereas fillers reshape and contour facial features.

    Press center

    Contacts




      Block background

      ZK MEDIGROUP CO. LTD

      22770 7F, Office 708, Cheongna-dong 202-3, Seo-gu, The Liv Tiamo Incheon, South Korea.

      E-Mail: INFO@ZKMEDIGROUP.COM

      Mob. Tel.: +82 10 5075-6622

      Go to google maps

      CYNEFILL PICO PDRN: biorevitalization with salmon DNA injection from the Korean factory

      Beautiful, firm, healthy facial skin is the main indicator of youth. Age, unfavorable environmental conditions, improper lifestyle, stress – negatively affect the condition of facial skin. 

      Evolution in cosmetology has given a procedure called biorevitalization. It is used to treat wrinkles, including around the eyes, dry skin, and also helps restore the water balance of the dermis. Biorevitalization guarantees rejuvenation of the injected area for several years.

      What is CYNEFILL PICO PDRN?

      Definition CYNEFILL PICO PDRN is a biostimulator for prolonged biorevitalization from a Korean manufacturer contains ingredients such as hyaluronic acid, PDRN, glutathione and niacinamide to repair and improve skin condition. 

      The agent is in ampoules with gel of transparent color, offered in a package of 5 pieces, 3 ml in each. Shelf life is 24 months from the date of manufacture. Injections can be performed to treat wrinkles and skin problems in the face, neck, décolletage, hands and body.

      Polydesoxyribonucleotide sodium, abbreviated as PDRN, is a substance isolated from fragments of salmon DNA. Clinical studies have shown that salmon DNA behavior has an excellent and significant effect on cell growth and tissue regeneration. It also improves skin elasticity, texture and moisturization.

      The scientific basis of PDRN and polydeoxyribonucleotides

      A polydesoxyribonucleotide is a linear polymer that consists of a mixture of double-stranded deoxyribonucleotides having a chain of 80-2200 base pairs and a molecular mass of 50 to 1500 kDa.

      Polydeoxyribonucleotide and PDRN are synthesized from salmon DNA. Serum based on fish sperm allows you to effectively fight the signs of aging. Injectables therapy after biorevitalization sessions shows excellent results in removing wrinkles, restoring fading, elasticity-lost skin, as well as enhancing metabolism and regeneration at the cellular level. 

      How salmon DNA promotes skin rejuvenation

      A substance extracted from salmon DNA, called polydesoxyribonucleotide, is a booster that acts at the cellular level. With its help, biorejuvenation is achieved. During microneedling the skin structure is restored, pigment spots are lightened, wrinkles are reduced and removed. The skin becomes moisturized, elastic and looks more youthful.

      Benefits of CYNEFILL PICO PDRN biorevitalization

      Biorevitalization has recently become one of the most popular cosmetic techniques. This popularity is justified by the high result and effect after the procedure.

      Benefits of revitalisation:

      • stimulation of collagen production;
      • skin moisturization;
      • the skin becomes more elastic, filled with moisture;
      • even out skin tone;
      • removal of age spots;
      • restoration of the deep layers of the dermis at the cellular level;
      • More radiantly healthy and beautiful skin;
      • elimination of wrinkles and the first signs of aging;
      • restoration of skin affected by UV radiation, use of poor-quality cosmetics, etc;
      • removal of dark circles under the eyes;
      • Smoothing of marks on the skin from pimples, scars, dark spots, acne.

      Collagen stimulation and skin elasticity

      After 25 years of age, collagen and ha, responsible for the condition of the skin gradually cease to be synthesized by the body. Therefore, cosmetologists advise using cosmetics with these ingredients in the composition. The lack of collagen leads to deterioration of the skin, it becomes sluggish and dry, wrinkles appear on it.

      Thanks to the injection of a biostimulator with salmon DNA, there is a natural acceleration of collagen stimulation at the cellular level. As a result of the regeneration process, human fibroblasts are restored and the skin becomes elastic and firm. Its surface is smoothed, rejuvenated, healthy and moisturized.

      Deep moisturizing with hyaluronic acid

      Our body produces hyaluronic acid in full until the age of 25-30. Then its production decreases, which causes the first wrinkles, dry skin, loss of elasticity and firmness.

      With CYNEFILL PICO PDRN injections, it is possible to replenish lost 

      to replenish moisture, nourish the skin with beneficial substances, and stop dehydration. Biostimulation helps to replenish the level of hyaluronic acid in the deepest subcutaneous layers. This technique is quite promising and gives instant results.

      Anti-aging effect and wrinkle reduction

      Over the years, the skin becomes drier, which causes the appearance of fine lines and wrinkles. Due to the lack of collagen, elastin and hyaluronic acid in the body, skin elasticity decreases, and the dermis becomes dull and inelastic. 

      Biorevitalization is the best option in this case. It will solve the problems with slack and dry skin in the neck and décolleté area. It will also help you to say goodbye to wrinkles and other facial problems.

      Areas affected by CYNEFILL PICO PDRN: face, neck and décolleté

      CYNEFILL PICO PDRN has an action on the face, neck and décolletage area.

      The following objectives are addressed in the facial treatment process:

      • wrinkles around the eyes and lips are smoothed out;
      • nasolabial folds are corrected;
      • the wrinkles on your forehead;
      • lighten the age spots;
      • acne marks, scars, scars, scars are removed.

      biostimulator injections with polynucleotides in the neck and décolleté are performed in case of fading skin that has lost its elasticity and firmness. It is also used to even out the tone of the dermis and lighten pigmentation.

      CYNEFILL PICO PDRN procedure

      The mechanism of biorevitalization with CYNEFILL PICO PDRN begins with a consultation and initial examination. The doctor carefully examines the desired areas of the procedure, determines the necessary amount of substance for injection. 

      Next, all cosmetics are removed from the face. All areas where the procedure will be performed are treated with antiseptic. Using a thin special needle, the preparation is injected into the deep layers of the dermis. After the introduction of the drug, the doctor again treats the surface with antiseptic and gives the necessary recommendations for further care. 

      Treatment plans and timelines for results

      The treatment plan is individualized depending on the problems at hand. The result of the treatment will be visible immediately.

      Recovery time and aftercare

      The recovery time depends on individual characteristics. Usually it does not exceed a week. In the period after the procedure, it is necessary to follow a few rules in order to maintain the anti-aging effect for as long as possible:

      • no sunbathing for two weeks;
      • there is a ban on peeling for 7-10 days;
      • for 3 days it is not recommended to visit saunas, swimming pools, baths, as well as overload in the gym;
      • in the first 12 hours after the procedure do not use decorative cosmetics. 

      How many treatments are required?

      The number of procedures, as well as the dose of the injected drug is determined by the doctor. Usually, a course of 3-8 procedures may be required to achieve maximum results, the interval between which can be from 7 to 10 days.

      Difference between biorevitalization and mesotherapy

      Biorevitalization and mesotherapy are two procedures that are used to rejuvenate the skin on the face and body. But they have several significant differences. The main difference between biorevitalization and mesotherapy lies in the injected drug, and accordingly, the goals of the procedure will also be different. 

      The basis of any preparation for biorevitalization is hyaluronic acid. Our skin needs it first of all to maintain water balance. Unfortunately, with age, the synthesis of this substance falls, which has a noticeable effect on the skin: it becomes flabby, loses elasticity and turgor, and in some cases may even be covered with wrinkles and lose its healthy color. Biorevitalization will help to correct all these flaws.

      The preparation for mesotherapy, as a rule, consists of many different components: lipolytics, vitamins, nutrients, the same hyaluronic acid, etc. The cocktail is always selected by a specialist individually for each patient. 

      Contraindications and precautions

      The procedure should be performed in a trusted clinic by an experienced specialist.  Also of great meaning are the preparations used. If they are cheap and of an unknown manufacturer, the effect of the procedure may be negative.  

      Who should avoid CYNEFILL PICO PDRN?

      Biorevitalization has the following contraindications:

      • pregnancy;
      • breastfeeding;
      • Oncology;
      • epilepsy;
      • autoimmune diseases;
      • colds and viral diseases accompanied by fever;
      • blood disorders;
      • irritation or inflammation at the injection site;
      • diabetes;
      • allergic reactions to the components of the drug;
      • a tendency to form keloid scars.

      FDA approval and safety standards

      DAWN salmon DNA products are FDA approved and fully compliant with the required safety standards.

      How to order CYNEFILL PICO PDRN

      The drug CYNEFILL PICO PDRN can be purchased from our website by leaving an application through the feedback form. We are a manufacturer located in South Korea.  All the latest information about the product can be found on the website.