CYNEFILL NAD+
Rejuvenation
at the cellular level

An innovative skin booster with NAD+ and PLA that restores cellular energy, stimulates collagen and protects DNA.
A new generation solution for skin rejuvenation from the inside.

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ZK MediGroup | Cynefill NAD+ ZK MediGroup | Cynefill NAD+ ZK MediGroup | Cynefill NAD+
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    ZK MediGroup | Cynefill NAD+
    ZK MediGroup | Cynefill NAD+ ZK MediGroup | Cynefill NAD+

    What is Nicotinamide Adenine Dinucleotide (NAD)?

    Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in living cells. It plays a crucial role in cellular metabolism, energy production, DNA repair, critical, and the prevention of aging.

    • ZK MediGroup | Cynefill NAD+ Energy Production: During cellular respiration, NAD+ takes up electrons and is converted to NADH, which helps generate ATP (cellular energy) in the mitochondria.
    • ZK MediGroup | Cynefill NAD+ Enzyme Regulation: NAD+ acts as an electron acceptor or donor, regulating sirtuin (SIRT) enzymes in skin cells that influence aging, gene transcription, and other cellular processes.
    • ZK MediGroup | Cynefill NAD+ Link to Aging: NAD+ availability declines with age. As NAD+ levels fall, the body's ability to generate cellular energy and repair DNA declines, leading to visible signs of aging.

    Nicotinamide mononucleotide (NMN) is an innovative precursor to nicotinamide adenine dinucleotide (NAD+). NAD+ is a coenzyme involved in over 500 biological processes, including the production of ATP (cellular energy) through electron transport in cells and the activation of SIRT1, which is responsible for autophagy (repair of damaged DNA).

    NAD+ availability declines with age. As NAD+ levels decline, the body's ability to generate cellular energy and repair DNA declines, leading to visible signs of aging. There have been several human clinical studies of NMN that have shown significant results in increasing NAD+ levels during exercise, as well as improving insulin sensitivity and aerobic capacity.

    ZK MediGroup | Cynefill NAD+

    Role of NAD+ in CYNEFILL®

    CYNEFILL® NAD+ is a new generation of skin rejuvenation solutions that target the root causes of degeneration at the cellular level. Unlike traditional treatments that temporarily mask the signs of aging, NAD+ acts at the cellular level.

    The product replenishes NAD+ levels, helping to repair DNA, increase cellular energy and stimulate collagen production. The result is noticeably firmer, smoother and more radiant skin.

    With its unique ability to restore and protect the skin from within, CYNEFILL® NAD+ enhances the skin's natural ability to regenerate, improves its texture and elasticity, reduces fine lines, dullness and signs of fatigue.

    ZK MediGroup | Cynefill NAD+ ZK MediGroup | Cynefill NAD+

    The uniqueness
    of nad+ in cynefill®

    01 fact 1.

    Efficacy/action confirmed by research

    Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in all living cells that plays a key role in cellular metabolism, energy production, DNA repair and anti-aging. NAD+ levels are directly related to the aging process, confirming its fundamental role in healthy and youthful skin.

    02 fact 2.

    Contains key cellular activators

    NAD+ acts as an electron acceptor or donor, regulating sirtuin enzymes (SIRT) in skin cells. Sirtuins influence various cellular processes, including cell aging, gene transcription and stress resistance. CYNEFILL® NAD+ triggers skin renewal processes from the inside out, activating energy metabolism and stimulating enzymes responsible for DNA repair and protection.

    03 fact 3.

    Works at the cellular level

    Unlike traditional products that temporarily mask the signs of aging, NAD+ works at the cellular level, attacking the root causes of skin degeneration. The product replenishes NAD+ levels, helping to repair DNA, increase cellular energy and stimulate collagen production, which provides a deep and long-lasting rejuvenating effect.

    Specifications

    Packaging

    Dry ampoule (120 mg) / Solvent (6 ml)

    Dry ampoule (120 mg)

    ZK MediGroup | Cynefill NAD+
    Nicotinamide adenine dinucleotide (NAD+) (25%)

    Coenzyme essential for cellular energy and metabolism, supports anti-aging processes

    ZK MediGroup | Cynefill NAD+
    Nicotinamide mononucleotide (NMN)

    Precursor of NAD⁺, helps boost energy, metabolism, and healthy aging

    ZK MediGroup | Cynefill NAD+
    Hyaluronic acid

    Biodegradable polymer, stimulates collagen production and skin firmness

    ZK MediGroup | Cynefill NAD+
    Polylactic acid (PLA)

    Natural moisturizer, improves skin elasticity and hydration

    Solvent (6 ml)

    • ZK MediGroup | Cynefill NAD+ Peptides
    • ZK MediGroup | Cynefill NAD+ Hyaluronic acid
    • ZK MediGroup | Cynefill NAD+ Glutathione
    • ZK MediGroup | Cynefill NAD+ Niacinamide
    • ZK MediGroup | Cynefill NAD+ Sodium DNA
    • ZK MediGroup | Cynefill NAD+ Ascorbic acid
    • ZK MediGroup | Cynefill NAD+ Cyanocobalamin
    • ZK MediGroup | Cynefill NAD+ Trehalose
    ZK MediGroup | Cynefill NAD+
    • Peptides ZK MediGroup | Cynefill NAD+
    • Hyaluronic acid ZK MediGroup | Cynefill NAD+
    • Glutathione ZK MediGroup | Cynefill NAD+
    • Niacinamide ZK MediGroup | Cynefill NAD+
    ZK MediGroup | Cynefill NAD+
    • ZK MediGroup | Cynefill NAD+ Sodium DNA
    • ZK MediGroup | Cynefill NAD+ Ascorbic acid
    • ZK MediGroup | Cynefill NAD+ Cyanocobalamin
    • ZK MediGroup | Cynefill NAD+ Trehalose

    Application areas

    CYNEFILL® NAD+ is designed to address a wide range of aesthetic skin concerns on the face, avoiding the area around the eyes, neck, and décolleté.

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    ZK MediGroup | Cynefill NAD+

    Aging skin: fine lines, wrinkles and sagging.

    ZK MediGroup | Cynefill NAD+

    Dull or dehydrated skin: skin lacking elasticity and radiance

    ZK MediGroup | Cynefill NAD+

    Photoaging: skin damage caused by ultraviolet radiation

    ZK MediGroup | Cynefill NAD+

    Loss of elasticity and density of the skin.

    ZK MediGroup | Cynefill NAD+

    Uneven skin tone or texture

    ZK MediGroup | Cynefill NAD+

    Prevention of aging: within the framework of the appropriate protocol.

    ZK MediGroup | Cynefill NAD+

    Thinning or fragility of the skin: age- or environment-related fragility

    ZK MediGroup | Cynefill NAD+

    Aging skin: fine lines, wrinkles and sagging.

    ZK MediGroup | Cynefill NAD+

    Dull or dehydrated skin: skin lacking elasticity and radiance

    ZK MediGroup | Cynefill NAD+

    Photoaging: skin damage caused by ultraviolet radiation

    ZK MediGroup | Cynefill NAD+

    Loss of elasticity and density of the skin.

    ZK MediGroup | Cynefill NAD+

    Uneven skin tone or texture

    ZK MediGroup | Cynefill NAD+

    Prevention of aging: within the framework of the appropriate protocol.

    ZK MediGroup | Cynefill NAD+

    Thinning or fragility of the skin: age- or environment-related fragility

    CYNEFILL® NAD+ can help with

    • ZK MediGroup | Cynefill NAD+ Reduce fine lines, wrinkles and age spots
    • ZK MediGroup | Cynefill NAD+ Reduce redness and irritation
    • ZK MediGroup | Cynefill NAD+ Smooth out uneven skin texture
    • ZK MediGroup | Cynefill NAD+ Increase cellular energy and stimulate collagen production
    • ZK MediGroup | Cynefill NAD+ Protect cells from oxidative stress
    • ZK MediGroup | Cynefill NAD+ Reduction of pigmentation
    • ZK MediGroup | Cynefill NAD+ Improve skin hydration and elasticity
    • Reduce fine lines, wrinkles and age spots
      ZK MediGroup | Cynefill NAD+
    • Reduce redness and irritation
      ZK MediGroup | Cynefill NAD+
    • Smooth out uneven skin texture
      ZK MediGroup | Cynefill NAD+
    • Increase cellular energy and stimulate collagen production
      ZK MediGroup | Cynefill NAD+
    ZK MediGroup | Cynefill NAD+ ZK MediGroup | Cynefill NAD+
    • ZK MediGroup | Cynefill NAD+
      Protect cells from oxidative stress
    • ZK MediGroup | Cynefill NAD+
      Reduction of pigmentation
    • ZK MediGroup | Cynefill NAD+
      Improve skin hydration and elasticity

    Main effects of NAD+ on skin

    ZK MediGroup | Cynefill NAD+
    ZK MediGroup | Cynefill NAD+

    Cellular Rejuvenation

    NAD+ activates fibroblasts and stimulates the production of collagen, elastin and hyaluronic acid. This results in:

    • ZK MediGroup | Cynefill NAD+ Increased skin elasticity and density
    • ZK MediGroup | Cynefill NAD+ Reduction of wrinkles
    • ZK MediGroup | Cynefill NAD+ Improved skin texture, making it smoother
    ZK MediGroup | Cynefill NAD+

    Increased Cellular Energy

    NAD+ helps generate ATP in the mitochondria, which is necessary for vital DNA repair and skin regeneration processes

    ZK MediGroup | Cynefill NAD+

    DNA Repair

    Increasing NAD+ levels helps repair damaged DNA, which slows down the aging process at the cellular level

    ZK MediGroup | Cynefill NAD+

    Antioxidant protection

    NAD+ protects cells from oxidative stress, which is a key contributor of skin aging, and strengthens their defense against external factors.

    ZK MediGroup | Cynefill NAD+

    Tone & Radiance Normalizer

    NAD+ helps even out skin tone and reduce dullness for a natural-looking glow

    ZK MediGroup | Cynefill NAD+

    Repair and Heal

    NAD+ helps skin recover from damage and improves its natural ability to regenerate

     Comparison with classical skin boosters (Hyaluronic Acid)

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    Criterion

    Mechanism of action
    Key component
    Effects
    Duration
    Impact area
    Results

    CYNEFILL® NAD+

    Cellular level: DNA repair, mitochondrial activation, collagen and elastin stimulation
    NAD+, PLA (polylactic acid), peptides
    Rejuvenation, increased cellular energy, elasticity, radiance, protection from oxidative stress
    6–8 months (thanks to biostimulation and cell regeneration)
    Deep mechanisms of skin aging (mitochondria, DNA)
    A more comprehensive and prolonged rejuvenating effect

    Hyaluronic acid (HA)

    Surface hydration and moisture retention
    Hyaluronic acid
    Moisturizing, improved elasticity
    3–4 months (the effect decreases as the HA degrades)
    Extracellular matrix (skin hydration)
    A fast but temporary moisturizing effect

    What to choose for your skin: NAD+ or mesotherapy?

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    Parameter

    ZK MediGroup | Cynefill NAD+
    Mechanism
    of action
    ZK MediGroup | Cynefill NAD+
    Depth
    of action
    ZK MediGroup | Cynefill NAD+
    Time
    of effect
    ZK MediGroup | Cynefill NAD+
    Pros

    NAD+ (injections)

    Subcutaneous injections → deep cellular restoration: DNA, mitochondria
    Penetrates deeper into the dermis and cells → systemic skin rejuvenation
    Gradual cumulative improvement of skin structure, long-term result
    Stimulation of natural rejuvenation processes, deep cellular regeneration

    Mesotherapy / Peptide cocktails

    Cocktail injections → local nutrition, collagen stimulation
    Mainly dermis → superficial improvement of elasticity and hydration
    Extracellular matrix (skin hydration)
    Instant hydration and lifting, local effect

    Contraindications

    • ZK MediGroup | Cynefill NAD+ Pregnancy and breastfeeding
    • ZK MediGroup | Cynefill NAD+ Active skin infections or inflammation
    • ZK MediGroup | Cynefill NAD+ Autoimmune skin diseases
    • ZK MediGroup | Cynefill NAD+ History of cancer or ongoing cancer treatment
    • ZK MediGroup | Cynefill NAD+ Uncontrolled chronic diseases
    • ZK MediGroup | Cynefill NAD+ Use of anticoagulants or blood clotting disorders
    • ZK MediGroup | Cynefill NAD+ Allergy to ingredients
    • ZK MediGroup | Cynefill NAD+ Recent aggressive aesthetic procedures
    ZK MediGroup | Cynefill NAD+ ZK MediGroup | Cynefill NAD+

    NAD+ Application Protocol

    ZK MediGroup | Cynefill NAD+
    ZK MediGroup | Cynefill NAD+

    1 session

    in 1-2 weeks

    2 session

    in 1-2 weeks

    3 session

    Maintenance course every 6 months

    1 session

    2 session

    3 session

    in 1-2 weeks
    in 1-2 weeks
    Maintenance course every 6 months

    HOW DOES THE CYNEFILL® NAD+ INJECTION PROCEDURE PERFORMED?

    Recommendation

    Before the procedure, a consultation with a doctor is required. The doctor will examine the problem area, collect anamnesis (medical history) and recommend additional procedures to achieve the best result

    Carrying out the procedure

    The CYNEFILL® NAD+ injection procedure is similar to mesotherapy and includes the following technical parameters:
    • 1

      Depth

      1–4 mm into the dermis, at an angle of approximately 45°
    • 2

      Techniques: Microinjections

      For even distribution of the drug, it is recommended to maintain a distance of 1 cm between injection sites
    • 3

      Needle size

      30–32G, 4–6 mm
    • 4

      Quantity

      0.01–0.05 ml per injection
    ZK MediGroup | Cynefill NAD+
    ZK MediGroup | Cynefill NAD+
    The duration of the effect of mesotherapy depends on the introduced drug, the introduction technique, the doctor`s experience
    ZK MediGroup | Cynefill NAD+ Usually lasts 6-8 months

    Why CYNEFILL® NAD+ is the Next Generation of Rejuvenation?

    ZK MediGroup | Cynefill NAD+

    Activation of Cellular Energy

    NAD+ restores mitochondrial function and increases energy production in skin cells, slowing down the appearance of signs of aging

    ZK MediGroup | Cynefill NAD+

    DNA Repair

    Acts on the root causes of aging, helps restore DNA and stimulates collagen synthesis

    ZK MediGroup | Cynefill NAD+

    Collagen stimulation

    8.5% polylactic acid triggers collagen synthesis and strengthens the structural integrity of the skin

    ZK MediGroup | Cynefill NAD+

    Peptide Synergy

    Peptide complex improves hydration, smoothes wrinkles and enhances cell interaction

    ZK MediGroup | Cynefill NAD+

    Visible results

    Skin becomes smoother, more radiant and looks younger just a few sessions

    ZK MediGroup | Cynefill NAD+

    Not intravenous

    The product is designed for aesthetic procedures - microinjections, which makes it safe and comfortable

    Frequently ask questions

    • What is NAD+ and why does the skin need it?

      NAD+ is a coenzyme involved in energy production and cell DNA repair in cells. In the skin, it slows down ageing, increases elasticity, and improves radiance.

    • What are the main benefits of the procedure?
      • ZK MediGroup | Cynefill NAD+
        Moisturizing and improving elasticity
      • ZK MediGroup | Cynefill NAD+
        Stimulating collagen and DNA repair
      • ZK MediGroup | Cynefill NAD+
        Radiant and elastic skin after just a few sessions
    • How is CYNEFILL® NAD+ different from conventional cosmetics?

      Unlike creams and serums, CYNEFILL® NAD+ works at the cellular level: replenishes NAD+, activates mitochondria and stimulates natural skin regeneration.

    • How is the CYNEFILL® NAD+ injection procedure performed?

      The drug is administered by microinjections to a depth of 1–4 mm. A course of 3 procedures with an interval of 1–2 weeks is recommended, then maintenance sessions every 6 months.

    • How safe is the procedure?

      The procedure is certified, safe and does not require intravenous administration.
      The composition undergoes strict quality control.

    • Are there any contraindications?

      Yes, contraindications include: pregnancy and breastfeeding, skin infections, autoimmune and oncological diseases, severe chronic diseases, taking anticoagulants, allergies to components.

    • When can I expect results?

      The first improvements in skin hydration and radiance are noticeable after 1-2 sessions.
      After a full course, the skin becomes more elastic, wrinkles are reduced.

    • Who is CYNEFILL® NAD+ suitable for?

      The product is recommended for the first signs of aging, dull or dehydrated skin, photoaging and loss of elasticity, as well as in preventive anti-age protocols.

    • How is CYNEFILL® NAD+ different from classic mesotherapy or fillers?

      CYNEFILL® NAD+ acts at the cellular level, restoring mitochondria and DNA, while mesotherapy and fillers work superficially – moisturizing or contouring the skin.

    • How long does the effect last and how to maintain it?

      The effect after the course lasts 4-6 weeks. Maintenance procedures every 4-6 months consolidate and enhance the result.

    • Can it be combined with other procedures?

      Yes, the product can be combined with some injection procedures. However, we recommend that you agree on the sequence with your cosmetologist and keep an interval of at least 1-2 weeks between procedures.

    • Is it painful to inject the drug?

      The procedure is almost painless. Microinjection technique is used, local anesthesia if necessary.

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    Contacts


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      ZK MEDIGROUP CO. LTD

      22770 7F, Office 708, Cheongna-dong 202-3, Seo-gu, The Liv Tiamo Incheon, South Korea.

      E-Mail: INFO@ZKMEDIGROUP.COM

      Mob. Tel.: +82 10 5302 5075

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